Structure of PDB 8ftj Chain A Binding Site BS01

Receptor Information
>8ftj Chain A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QNPDLLELCHSVPKEVVQLGGKGYDFAAFRAWLRCYGMPGMSSLQDRHGR
TIWFQGDPGPLAP
Ligand information
Receptor-Ligand Complex Structure
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PDB8ftj Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		G2 E3 E6 K54 R78 M81 R118 F120 R122 Q130 R133 Q168 G175 N176 K242 Y263 R277 T278
Binding residue
(residue number reindexed from 1)		G1 E2 E5 K53 R77 M80 R117 F119 R121 Q129 R132 Q167 G174 N175 K222 Y236 R250 T251
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8ftj, PDBe:8ftj, PDBj:8ftj
PDBsum8ftj
PubMed37014002
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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