Structure of PDB 8fpl Chain A Binding Site BS01

Receptor Information

>8fpl Chain A (length=256) Species: 10116 (Rattus norvegicus)

KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVF
DKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP
CDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWW
YDKGEC

Ligand information

• Ligand ID: Y4Y
• InChI: InChI=1S/C9H8N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,3,10H2,(H,11,14)(H,12,15)
• InChIKey: DWQWOEGFPYFGFJ-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: c1c(c(cc2c1NC(=O)C(=O)N2)N(=O)=O)CN
  CACTVS 3.385: NCc1cc2NC(=O)C(=O)Nc2cc1[N](=O)=O
  ACDLabs 12.01: O=N(=O)c1cc2NC(=O)C(=O)Nc2cc1CN
• Formula: C9 H8 N4 O4
• Name: 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione
• PDB chain: 8fpl Chain A Residue 901

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fpl The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
• Resolution: 2.81 Å
• Binding residue (original residue number in PDB): E402 Y450 P478 T480 R485 Y732
• Binding residue (residue number reindexed from 1): E10 Y58 P86 T88 R93 Y215
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0015276 ligand-gated monoatomic ion channel activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006811 monoatomic ion transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8fpl, PDBe:8fpl, PDBj:8fpl
• PDBsum: 8fpl
• PubMed: 38409505
• UniProt: P19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)