Structure of PDB 8fke Chain A Binding Site BS01

Receptor Information

>8fke Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKIKFQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNL
DLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKP
FGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI
QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT
ETDMSLHPLLQEIYKDLY

Ligand information

>8fke Chain D (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SNLGLEDIIRKALM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fke Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR32904
Resolution	2.02 Å
Binding residue (original residue number in PDB)	V293 T297 K301 V315 L318 K319 H323
Binding residue (residue number reindexed from 1)	V84 T88 K92 V106 L109 K110 H114

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:8fke, PDBe:8fke, PDBj:8fke
PDBsum	8fke
PubMed
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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