BioLiP

Receptor Information

>8fk3 Chain A (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

>8fk3 Chain B (length=15) Species: 607682 (Adeno-associated virus - Po1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AKKRVYPKKKKARIE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fk3 Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	S105 E107 F138 W142 N146 A148 S149 G150 T151 T155 Q181 W184 N188 D192 W231 R238 W273 Y277 R315 V321 T322 G323 T324 W357 N361 A364 E396 W399
Binding residue (residue number reindexed from 1)	S34 E36 F67 W71 N75 A77 S78 G79 T80 T84 Q110 W113 N117 D121 W160 R167 W202 Y206 R244 V250 T251 G252 T253 W286 N290 A293 E325 W328

Enzyme Commision number

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

PDB	RCSB:8fk3, PDBe:8fk3, PDBj:8fk3
PDBsum	8fk3
PubMed	36851528
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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Structure of PDB 8fk3 Chain A Binding Site BS01