Structure of PDB 8fgw Chain A Binding Site BS01

Receptor Information
>8fgw Chain A (length=1081) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLESNLSMN
QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRN
KSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTW
SADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYH
GTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHM
GSVLAVAGFQKAVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIAL
AVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYV
KYVKGLISITTCGDFCILATKADATFVLVLCNSIGTPLDPKYIDIVPLFV
AMTKTHVIAASKEAFYTWQYRVASRKEGRERIYHVDDTPSGSMGVLDYSK
TIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQ
LSLNCNSSRLAIIDISGVLTFFDLDARVTVVGELLKLERRDVWDMKWAKD
NPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKD
PEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAE
AALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRF
EEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANN
AIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE
NHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVEL
AKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIA
DEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKFTDNAWRGAEAYHFFILA
QRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSK
AFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNKLPTCVATGSPITEY
QFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fgw Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fgw Human IFT-A complex structures provide molecular insights into ciliary transport.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C1155 C1158 C1173
Binding residue
(residue number reindexed from 1)		C1055 C1058 C1073
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0030030 cell projection organization
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0060271 cilium assembly
GO:0061512 protein localization to cilium
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
GO:0097542 ciliary tip

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fgw, PDBe:8fgw, PDBj:8fgw
PDBsum8fgw
PubMed36775821
UniProtQ9P2L0|WDR35_HUMAN WD repeat-containing protein 35 (Gene Name=WDR35)

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