Structure of PDB 8ffz Chain A Binding Site BS01

Receptor Information
>8ffz Chain A (length=314) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRPKTYFCDYDGCDKAFTRPSILTEHQLSVHQGLRAFQCDKCAKSFVKKS
HLERHLYTHSDTKPFQCSYCGKGVTTRQQLKRHEVTHTKSFICPEEGCNL
RFYKHPQLRAHILSVHLHKLTCPHCNKSFQRPYRLRNHISKHHDPEVENP
YQCTFAGCCKEFRIWSQLQSHIKNDHPKLKCPICSKPCVGENGLQMHMII
HDDSLVTKNWKCHICPDMSFSRKHDLLTHYGSIHTEEDIPLELKYKISNN
NVEFLQNEVDLEKRLESGENGLNLLLNTVGRKYRCFYNNCSRTFKTKEKY
EKHIDKHKVHELKL
Ligand information
>8ffz Chain I (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcatatcacctgcgtttccgttaaactatcggttgcggccatatctacca
gaaagcaccgtttcccgtccgatcaactgtagttaagctggtaagagcct
gaccgagtagtgtagtgggtgaccatacgcgaaactcaggtgctgcaatc
t
Receptor-Ligand Complex Structure
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PDB8ffz Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K58 K87 K91 H94 R97 H98 T101 K115 Q122 F134 H148 R152 K170 Q173 R177 K184 H185 R374 K381
Binding residue
(residue number reindexed from 1)		K15 K44 K48 H51 R54 H55 T58 K72 Q79 F91 H105 R109 K127 Q130 R134 K141 H142 R292 K299
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0042791 5S class rRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ffz, PDBe:8ffz, PDBj:8ffz
PDBsum8ffz
PubMed37402369
UniProtP39933|TF3A_YEAST Transcription factor IIIA (Gene Name=PZF1)

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