Structure of PDB 8fay Chain A Binding Site BS01
Receptor Information
>8fay Chain A (length=393) Species:
9606
(Homo sapiens) [
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LFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEV
MLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRR
LQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVV
DGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMEL
GATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLPWDQTLGVVNFP
RKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTW
EPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLA
LEGTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMG
Ligand information
>8fay Chain B (length=11) [
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aagacgtggac
Receptor-Ligand Complex Structure
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PDB
8fay
Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)
Resolution
1.91 Å
Binding residue
(original residue number in PDB)
Q139 Q141 G176 G178 Y179 Y180 K365 G396 L398 H444 F446 S447 H448 S487 T488
Binding residue
(residue number reindexed from 1)
Q54 Q56 G91 G93 Y94 Y95 K256 G287 L289 H335 F337 S338 H339 S373 T374
Enzymatic activity
Enzyme Commision number
3.2.2.31
: adenine glycosylase.
External links
PDB
RCSB:8fay
,
PDBe:8fay
,
PDBj:8fay
PDBsum
8fay
PubMed
UniProt
Q9UIF7
|MUTYH_HUMAN Adenine DNA glycosylase (Gene Name=MUTYH)
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