Structure of PDB 8f8y Chain A Binding Site BS01
Receptor Information
>8f8y Chain A (length=425) Species:
9606
(Homo sapiens) [
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NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKKSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYME
EHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKD
CKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVE
NYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFY
LIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGW
IYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETA
CWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHE
DELPEHFKPSQLIKDLAKEIRLSEN
Ligand information
>8f8y Chain E (length=7) Species:
9606
(Homo sapiens) [
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PRVKAAQ
Receptor-Ligand Complex Structure
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PDB
8f8y
A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
Resolution
3.06 Å
Binding residue
(original residue number in PDB)
Y14 V16 T17 F19 M20 E22 W29 E39 I45 Y145 E150 V178 D179 Y182
Binding residue
(residue number reindexed from 1)
Y15 V17 T18 F20 M21 E23 W30 E40 I46 Y126 E131 V159 D160 Y163
Enzymatic activity
Enzyme Commision number
1.14.11.-
External links
PDB
RCSB:8f8y
,
PDBe:8f8y
,
PDBj:8f8y
PDBsum
8f8y
PubMed
36596360
UniProt
O75151
|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)
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