Structure of PDB 8f8m Chain A Binding Site BS01

Receptor Information
>8f8m Chain A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKM
ADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHG
KEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREF
VCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQ
LLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f8m Isosteric improvements to liver receptor homolog-1 small molecule modulators
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R361 V371 Q374 M375 E534 M535
Binding residue
(residue number reindexed from 1)		R63 V73 Q76 M77 E236 M237
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:8f8m, PDBe:8f8m, PDBj:8f8m
PDBsum8f8m
PubMed
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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