Structure of PDB 8f88 Chain A Binding Site BS01

Receptor Information
>8f88 Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPF
DHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQ
KSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSY
YTVRQLELENLTTQETREILHFHYTTWPAFGVPESPASFLNFLFKVRESG
SLSPEHGPVVVHASAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLE
MRKFRMGLIATADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f88 Structure guided studies of the interaction between PTP1B and JAK.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y46 D48 F182 A215 S216 A217 I219 G220 R221
Binding residue
(residue number reindexed from 1)		Y44 D46 F180 A213 S214 A215 I217 G218 R219
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8f88, PDBe:8f88, PDBj:8f88
PDBsum8f88
PubMed37316570
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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