Structure of PDB 8f6p Chain A Binding Site BS01

Receptor Information
>8f6p Chain A (length=1091) Species: 6100,10116 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAI
YTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDSALRTF
RVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL
FMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTT
DVLLCGNSSDAGTCPEGYRCLKAGQNPDHGYTSFDSFAWAFLALFRLMTQ
DCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ
ATIAETEEPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTG
IFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGSVLRSFRLLRV
FKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNY
SELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQS
LCLLVFLLVMVIGNLVVLNLFLALLLSSFWWRLRKTCYRIVEHSWFETFI
IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY
GFKKYFTNAWCWLDFLIVDVSLVSLVANTIKSLRTLRALRPLRALSRFEG
MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEG
DLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFK
GWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVI
IDNFNQQKKKLGGQDIFMTEEQKKYYNMMKKLGSKKPQQGFIFDIVTKQA
FDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKM
AALRHYYFTNSWNIFDFVVVILSIVGTVLSDITLFRVIRLARIGRILRLI
RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG
IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNG
SRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVA
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain8f6p Chain A Residue 2206 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f6p Structural Basis for Inhibition of the Cardiac Sodium Channel by the Atypical Antiarrhythmic Drug Ranolazine
Resolution3.2 Å
Binding residue
(original residue number in PDB)		P1727 D1731 P1732
Binding residue
(residue number reindexed from 1)		P1038 D1042 P1043
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0008218 bioluminescence
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f6p, PDBe:8f6p, PDBj:8f6p
PDBsum8f6p
PubMed
UniProtP15389;
P42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP)

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