Structure of PDB 8f4b Chain A Binding Site BS01

Receptor Information
>8f4b Chain A (length=1182) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNPCPESSASFLSRITFWWITGMMVQGYRQPLESTDLWSLNKEDTSEQVV
PVLVKNWKKECAKSFKVLYKTFGPYFLMSFLFKAVHDLMMFAGPEILKLL
INFVNDKKAPEWQGYFYTALLFISACLQTLVLHQYFHICFVSGMRIKTAV
IGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPL
QVILALYLLWLNLGPSVLAGVAVMVLMVPLNAVMAMKTKTYQVAHMKSKD
NRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVG
TFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRFPLNIL
PMVISSIVQASVSLKRLRVFLSHEDLDPDSIQRRSITVKNATFTWARNDP
PTLHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVTVKGSV
AYVPQQAWIQNISLRENILFGRQLQERYYKAVVEACALLPDLEILPSGDR
TEIGEKGVNLSGGQKQRVSLARAVYCDSDVYLLDDPLSAVDAHVGKHIFE
NVIGPKGLLKNKTRLLVTHAISYLPQMDVIIVMSGGKISEMGSYQELLAR
DGAFAEFLRKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLW
TDDPIVNGTQEHTQVRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLH
LDLLHNVLRSPISFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLF
NVIGACIIILLATPMAAVIIPPLGLIYFFVQRFYVASSRQLKRLESVSRS
PVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWL
AVRLECVGNCIVLFASLFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVR
MSSEMETNIVAVERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYG
LRYREDLDLVLKHINVTIDGGEKVGIVGRTGAGKSSLTLGLFRIKESAEG
EIIIDDINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV
WTSLELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTK
ILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIV
LDKGEIQEWGSPSDLLQQRGLFYSMAKDSGLV
Ligand information
>8f4b Chain B (length=17) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YFWGNLHWYYEQFDSTC
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f4b A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation.
Resolution3.27 Å
Binding residue
(original residue number in PDB)		H382 F385 F389 R433 D436 T439 Y440 N480 M483 L545 A546 G549 W553 R593 F594 N597 I598 M601 M1092 E1203 N1244 W1245 R1248 E1252
Binding residue
(residue number reindexed from 1)		H133 F136 F140 R184 D187 T190 Y191 N231 M234 L296 A297 G300 W304 R344 F345 N348 I349 M352 M744 E855 N896 W897 R900 E904
Enzymatic activity
Enzyme Commision number 7.6.2.2: ABC-type xenobiotic transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f4b, PDBe:8f4b, PDBj:8f4b
PDBsum8f4b
PubMed36893260
UniProtQ8HXQ5|MRP1_BOVIN Multidrug resistance-associated protein 1 (Gene Name=ABCC1)

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