Structure of PDB 8f2q Chain A Binding Site BS01

Receptor Information
>8f2q Chain A (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8f2q Importin alpha / beta-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R315 N319 V321 G323 T328 E354 W357 N361 A364 E396 W399 N403 S406
Binding residue
(residue number reindexed from 1)		R244 N248 V250 G252 T257 E283 W286 N290 A293 E325 W328 N332 S335
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8f2q, PDBe:8f2q, PDBj:8f2q
PDBsum8f2q
PubMed36990397
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]