Structure of PDB 8ey2 Chain A Binding Site BS01

Receptor Information

>8ey2 Chain A (length=306) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSSGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ

Ligand information

>8ey2 Chain C (length=11) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SAVLQSGFRKM

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ey2 An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): T24 T25 T26 H41 L141 N142 G143 S145 H163 H164 M165 E166 P168 Q189
• Binding residue (residue number reindexed from 1): T24 T25 T26 H41 L141 N142 G143 S145 H163 H164 M165 E166 P168 Q189

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:8ey2, PDBe:8ey2, PDBj:8ey2
• PDBsum: 8ey2
• PubMed: 36941262
• UniProt: P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)