Structure of PDB 8exw Chain A Binding Site BS01

Receptor Information
>8exw Chain A (length=779) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGD
IVSVGLQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQ
RYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAI
SDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKGSLED
QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL
EKARVISQQSLERSYHIFYQIMSGSVPGVKEMCFLSDNIYDYYNVSQGKV
TVPNMDDGEEFQLADQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRG
REEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ
QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIF
EYNGFEQLCINFTNEKLQQFFNHIMFVMEQEEYKKEGINWDFIDFGMDLL
ACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKP
PKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLL
IEIFADHAGQKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMK
QPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYMILAPAI
MAAEKVAKNAAGKCLEAVGLDPDMYRIGHTKVFFRAGVLGQMEEFRDERL
GKIMSWMQAWARGYLSRKGFKKLQEQRVA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8exw Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8exw Drosophila melanogaster indirect flight muscle myosin II (subfragment-1)
Resolution2.5 Å
Binding residue
(original residue number in PDB)		T186 S241
Binding residue
(residue number reindexed from 1)		T178 S224
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8exw, PDBe:8exw, PDBj:8exw
PDBsum8exw
PubMed
UniProtP05661|MYSA_DROME Myosin heavy chain, muscle (Gene Name=Mhc)

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