Structure of PDB 8exv Chain A Binding Site BS01 |
>8exv Chain A (length=895) Species: 9606 (Homo sapiens)
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NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDL NSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSDKQKYTL KINHDCVPEQVIAEAIRKKTRSMYQGKYILKVCGCDEYFLEKYPLSQYKY IRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRTSTKSLWVINSA LRIKILCATYVNVNIIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNE WLNYDIYIPDLPRAARLCLSICSVEEHCPLAWGNINLFDYTDTLVSGKMA LNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVI EEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSE ITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPP IKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYE QYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYC RACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRP DFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEL LFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIG DCVGLIEVVRNSHTIMQIQCKFNSHTLHQWLKDKNKGEIYDAAIDLFTRS CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKRERVPFVL TQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMML GSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGW |
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Ligand ID | X3N |
InChI | InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1 |
InChIKey | SGEUNORSOZVTOL-CABZTGNLSA-N |
SMILES | Software | SMILES |
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OpenEye OEToolkits 2.0.7 | C[C@@H](C(=O)N)Nc1ccc-2c(c1)OCCn3c2nc(c3)N4[C@@H](COC4=O)C(F)F | CACTVS 3.385 | C[CH](Nc1ccc2c(OCCn3cc(nc23)N4[CH](COC4=O)C(F)F)c1)C(N)=O | CACTVS 3.385 | C[C@H](Nc1ccc2c(OCCn3cc(nc23)N4[C@@H](COC4=O)C(F)F)c1)C(N)=O | OpenEye OEToolkits 2.0.7 | CC(C(=O)N)Nc1ccc-2c(c1)OCCn3c2nc(c3)N4C(COC4=O)C(F)F | ACDLabs 12.01 | FC(F)C1COC(=O)N1c1nc2c3ccc(NC(C)C(N)=O)cc3OCCn2c1 |
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Formula | C18 H19 F2 N5 O4 |
Name | N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide |
ChEMBL | CHEMBL4650215 |
DrugBank | DB15275 |
ZINC | ZINC000669678973
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PDB chain | 8exv Chain A Residue 1101
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Enzyme Commision number |
2.7.11.1: non-specific serine/threonine protein kinase. 2.7.1.137: phosphatidylinositol 3-kinase. 2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase. |
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