Structure of PDB 8exn Chain A Binding Site BS01

Receptor Information
>8exn Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSP
FDHSRIKLHQNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQK
SRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYY
TVRQLELENLTTQETREILHFHYTTWPAFGVPESPASFLNFLFKVRESGS
LSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEM
RKFRMGLIATADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8exn Structure guided studies of the interaction between PTP1B and JAK.
Resolution2.151 Å
Binding residue
(original residue number in PDB)		D48 V49 F182 A217
Binding residue
(residue number reindexed from 1)		D47 V48 F179 A214
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8exn, PDBe:8exn, PDBj:8exn
PDBsum8exn
PubMed37316570
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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