Structure of PDB 8ew9 Chain A Binding Site BS01

Receptor Information
>8ew9 Chain A (length=241) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADATSVAVDASISAFPKKMGPPQWPFSTQYELIGKGVRCVSSITFKAYGL
GIYVAAEDKHLVSEVLDSKFLSQAFIDTAAPPSPENSHQDNLRAALNDPA
KAPILINNLLDSGIRLMSKNTPIKAGSFKLLMDGTKKSVLKNPDSQSQDK
DRLEAGFQELHDCFRSVKGLVARDDDFFIELNKDCSMNLSYYARKKDEFV
ILGTVKEPLIGKLLFAHYLAAVDPPSPEARKEVIDALVSLS
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain8ew9 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ew9 Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R107 Y117 N189 T204
Binding residue
(residue number reindexed from 1)		R38 Y48 N120 T135
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016872 intramolecular lyase activity

View graph for
Molecular Function
External links
PDB RCSB:8ew9, PDBe:8ew9, PDBj:8ew9
PDBsum8ew9
PubMed36739946
UniProtP38885|AIM46_YEAST Altered inheritance of mitochondria protein 46, mitochondrial (Gene Name=AIM46)

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