Structure of PDB 8eti Chain A Binding Site BS01

Receptor Information

>8eti Chain A (length=254) Species: 4896 (Schizosaccharomyces pombe)

SAGFVPIKQKVLVLSSRGVTYRQRHLLNDLVSMMPHSKKDSKLDSKDRLY
QLNELAELYNCNNIFFFESRRREDLYLHIARAPNGPTVKFHVENLHTMDE
LNMTGNALKGSRPILSFDKTFDTAPHLKVVKELLQQTFGIPKGARRSKPF
IDRVCTLTIADGKIWFRNYEIRENVTLIEIGPRFVMTIINILEGSFGGPV
IYKNDTFVSSTMVRAAIRNQAAQRYVNRQESKLERQVRAQQNVIPEDPLD
NVFA

Ligand information

>8eti Chain 1 (length=1579)

uugaccucaaaucagguaggacuacgcgcugauaagcgcaggaaaagaaa
auaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaa
aucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcu
uugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagg
gugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucg
aagagucgaguugcagcucuaaauggguggucaucuaaagcuaaauauug
gcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacu
uugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauugg
aaaucagucuuaccugggugagaucaguagucucucgagacuaugcacuc
uaaccuggguaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
cuaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaa
aacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaaaga
gcauagcuguugggacccgaaagauggugaaccaucuaguagcugguucc
ugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguaugua
aaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcg
ggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaag
aaaagguguuaguucaucuagacagcaggacgguggccauggaagucgga
auccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccuga
aaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagc
uuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcagcgaaaccacagccuggggggccaggcaaaaucagcggcagucaag
cgcgacguugcuuuccuaucauaccgaagcagaauucgguaagcguggga
acugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaacc
guugauucagaucauugguauuugcggcgccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgaa
uguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcga
ugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaucg
aauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugc
ugagauuaagccuuuguucccaagauuug

........................<<<<<<....>>>>>.>.........
<<....>>..<<<<<......<<>>.....>>>>>..<<<..<.......
.<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<
<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<
<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>.
.......<<<<<<>>>>>>.....<<<<<..>>>>>..>>>.........
.........................<<....>>...............<<
<<....>>>>..................................<<<<<<
<<<<<<.....<<<<<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>
>.>>>>>>>>..<<<<<<<<<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>....>>>>>>>>....>>>>>>>>>>>>..<<<<
.....>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<......
.>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>......
>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<
<<<<......<<..>>..<<<<<<<<<<...<<<.<<<<<<<....>>>>
>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...
...<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>.
...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<....
.<<.>>....>>....<<<<<....>>>>>....<<<<<.<<<<<<...<
..>...>>>>>>.<<<...<.<<<<<<<......>>>>>>>...>.>>>.
.>>>>>......<<<<<<<..<<<<.<.<<<<<.................
>>>>>.><<<<<....<.<....<<<<..>>>>...>.>...>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>.
...<<.......<<<<<<...>>.>>>>....>>........<<<<<...
.<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<
<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>
...>>>....>>>>.>>>>>...>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eti Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): Y266 R269 R276 R279
• Binding residue (residue number reindexed from 1): Y225 R228 R235 R238

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0032153 cell division site

External links

• PDB: RCSB:8eti, PDBe:8eti, PDBj:8eti
• PDBsum: 8eti
• PubMed: 36423630
• UniProt: Q9HGL6|BRX1_SCHPO Ribosome biogenesis protein brx1 (Gene Name=brx1)