Structure of PDB 8esv Chain A Binding Site BS01

Receptor Information
>8esv Chain A (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRN
ISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYV
FTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQN
YGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIM
YARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQ
GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAF
KSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQC
AGSICEKYGLEECTCDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTI
TLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8esv Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8esv Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		I459 C460 N462 M464 E469 D472
Binding residue
(residue number reindexed from 1)		I242 C243 N245 M247 E252 D255
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.81: ADAM10 endopeptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8esv, PDBe:8esv, PDBj:8esv
PDBsum8esv
PubMed37516108
UniProtO14672|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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