Structure of PDB 8eq5 Chain A Binding Site BS01

Receptor Information
>8eq5 Chain A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYA
MKVLKKATLKVRDRVRLVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL
FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG
HIKLTDFGLSKESHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL
MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNP
ANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP
Ligand information
Receptor-Ligand Complex Structure
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PDB8eq5 The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		K284 L285 M287 R300 F303 K304 R305 N306 N309
Binding residue
(residue number reindexed from 1)		K227 L228 M230 R243 F246 K247 R248 N249 N252
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8eq5, PDBe:8eq5, PDBj:8eq5
PDBsum8eq5
PubMed37149146
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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