Structure of PDB 8epl Chain A Binding Site BS01

Receptor Information
>8epl Chain A (length=1274) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI
FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTLRTLRA
VRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLE
FYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQ
FDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFF
VLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAE
EVMLAEEIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYA
EFLFLGLFLLEMSLKSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLR
ALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGM
QLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG
VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA
FNQKHALQHHMSVWEQRTSQLRKHMQMIRRACHYIVNLRYFEMCILLVIA
ASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILLW
NILDFVVVVGALVAFALANALRDIKTIKSLRVLRVLRPLKTIKRLPKLKA
VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK
ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQV
LQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQ
EQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVS
PSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVL
KVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKL
FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ
VFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG
CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFE
YLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGL
GKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGAD
RQQLDSELQKETLAIWPHLSQKML
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8epl Chain A Residue 2401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8epl Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E309 E657 E1372
Binding residue
(residue number reindexed from 1)		E218 E485 E795
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0008331 high voltage-gated calcium channel activity
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007268 chemical synaptic transmission
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0043025 neuronal cell body
GO:0045202 synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8epl, PDBe:8epl, PDBj:8epl
PDBsum8epl
PubMed36446785
UniProtQ15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (Gene Name=CACNA1E)

[Back to BioLiP]