Structure of PDB 8eio Chain A Binding Site BS01
Receptor Information
>8eio Chain A (length=1162) Species:
9606
(Homo sapiens) [
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MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLS
EKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPL
LLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGM
QMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHF
VWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQ
RAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAV
TRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF
WEGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKH
SGRISFCSQFSWIMPGTIKENIIGVSYDEYRYRSVIKACQLEEDISKFAE
KDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKE
IFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQN
LWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGSYAVIITST
SSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAV
LQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLK
GLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIF
FIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSV
SRVFKFIDMPTEGIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQR
VGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVL
VDGGCVLSHGHKQLMCLARSVLSKAKILLLDQPSAHLDPVTYQIIRRTLK
QAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQ
AISPSDRVKLFP
Ligand information
>8eio Chain B (length=17) Species:
9606
(Homo sapiens) [
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AAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB
8eio
Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
L34 D47 T1076 K1080 L1084
Binding residue
(residue number reindexed from 1)
L34 D47 T816 K820 L824
Enzymatic activity
Enzyme Commision number
5.6.1.6
: channel-conductance-controlling ATPase.
Gene Ontology
Molecular Function
GO:0005254
chloride channel activity
GO:0005260
intracellularly ATP-gated chloride channel activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0015106
bicarbonate transmembrane transporter activity
GO:0015108
chloride transmembrane transporter activity
GO:0016853
isomerase activity
GO:0016887
ATP hydrolysis activity
GO:0017081
chloride channel regulator activity
GO:0019869
chloride channel inhibitor activity
GO:0019899
enzyme binding
GO:0030165
PDZ domain binding
GO:0042626
ATPase-coupled transmembrane transporter activity
GO:0043225
ATPase-coupled inorganic anion transmembrane transporter activity
GO:0051087
protein-folding chaperone binding
GO:0071889
14-3-3 protein binding
GO:0106138
Sec61 translocon complex binding
GO:0140359
ABC-type transporter activity
Biological Process
GO:0006695
cholesterol biosynthetic process
GO:0006811
monoatomic ion transport
GO:0006821
chloride transport
GO:0006904
vesicle docking involved in exocytosis
GO:0015701
bicarbonate transport
GO:0030301
cholesterol transport
GO:0034220
monoatomic ion transmembrane transport
GO:0034976
response to endoplasmic reticulum stress
GO:0035377
transepithelial water transport
GO:0035774
positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045921
positive regulation of exocytosis
GO:0048240
sperm capacitation
GO:0050891
multicellular organismal-level water homeostasis
GO:0051454
intracellular pH elevation
GO:0051649
establishment of localization in cell
GO:0055085
transmembrane transport
GO:0060081
membrane hyperpolarization
GO:0070175
positive regulation of enamel mineralization
GO:0071320
cellular response to cAMP
GO:0097186
amelogenesis
GO:1902161
positive regulation of cyclic nucleotide-gated ion channel activity
GO:1902476
chloride transmembrane transport
GO:1902943
positive regulation of voltage-gated chloride channel activity
GO:1904322
cellular response to forskolin
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005765
lysosomal membrane
GO:0005768
endosome
GO:0005769
early endosome
GO:0005783
endoplasmic reticulum
GO:0005789
endoplasmic reticulum membrane
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0009986
cell surface
GO:0010008
endosome membrane
GO:0016020
membrane
GO:0016324
apical plasma membrane
GO:0030660
Golgi-associated vesicle membrane
GO:0030669
clathrin-coated endocytic vesicle membrane
GO:0031901
early endosome membrane
GO:0032991
protein-containing complex
GO:0034707
chloride channel complex
GO:0055037
recycling endosome
GO:0055038
recycling endosome membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8eio
,
PDBe:8eio
,
PDBj:8eio
PDBsum
8eio
PubMed
36264792
UniProt
P13569
|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)
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