Structure of PDB 8ei8 Chain A Binding Site BS01

Receptor Information
>8ei8 Chain A (length=374) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR
RRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQI
NPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL
KDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGG
ESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFD
EKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKR
IRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNR
LDLPPYKSYEQLREKLLYAIEETE
Ligand information
>8ei8 Chain B (length=17) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DPANWECRYAAFNCFIQ
Receptor-Ligand Complex Structure
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PDB8ei8 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution2.9 Å
Binding residue
(original residue number in PDB)		F495 R496 Y499 R561 E562 F565 K620 F621 C750 M752 Q753 E789
Binding residue
(residue number reindexed from 1)		F4 R5 Y8 R70 E71 F74 K129 F130 C259 M261 Q262 E298
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei8, PDBe:8ei8, PDBj:8ei8
PDBsum8ei8
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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