Structure of PDB 8ei6 Chain A Binding Site BS01

Receptor Information
>8ei6 Chain A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR
RRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQI
NPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL
KDLESIDPEFYNSIVWIKENNLYFIQDMEILGKVTTHELKEGGESIRVTE
ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELM
LCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV
TGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYK
SYEQLREKLLYAIEETE
Ligand information
>8ei6 Chain C (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PATIMCRAAADTCTFF
Receptor-Ligand Complex Structure
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PDB8ei6 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution3.62 Å
Binding residue
(original residue number in PDB)		Y499 H500 R503 F504 H507 G619
Binding residue
(residue number reindexed from 1)		Y8 H9 R12 F13 H16 G128
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei6, PDBe:8ei6, PDBj:8ei6
PDBsum8ei6
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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