Structure of PDB 8ei4 Chain A Binding Site BS01

Receptor Information
>8ei4 Chain A (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLR
RRLYVIFDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNLQINPASTINPD
HLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTE
FYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEEN
KDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLC
GMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTG
TCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY
EQLKEKLLFAIEETE
Ligand information
>8ei4 Chain B (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PASMRCHRAAHICSVL
Receptor-Ligand Complex Structure
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PDB8ei4 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution2.43 Å
Binding residue
(original residue number in PDB)		E702 F703 S706 W709 C718 L720 M722 M760
Binding residue
(residue number reindexed from 1)		E150 F151 S154 W157 C166 L168 M170 M208
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei4, PDBe:8ei4, PDBj:8ei4
PDBsum8ei4
PubMed37914719
UniProtQ9H0M0|WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 (Gene Name=WWP1)

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