Structure of PDB 8ei2 Chain A Binding Site BS01

Receptor Information
>8ei2 Chain A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK
IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKP
FCQLEITLMNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLG
EAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAP
SYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNAL
VTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHII
SAGLADMVAAAETITTDSEKYREQLDTLFNRFSKLVKEAFQDDPRFLTAR
DKAYKAVV
Ligand information
>8ei2 Chain C (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PAWYDCADAAWICTF
Receptor-Ligand Complex Structure
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PDB8ei2 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution2.8 Å
Binding residue
(original residue number in PDB)		W40 F41 F44 H48 K109 Q113
Binding residue
(residue number reindexed from 1)		W30 F31 F34 H38 K99 Q103
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ei2, PDBe:8ei2, PDBj:8ei2
PDBsum8ei2
PubMed37914719
UniProtQ93034|CUL5_HUMAN Cullin-5 (Gene Name=CUL5)

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