Structure of PDB 8ei1 Chain A Binding Site BS01

Receptor Information
>8ei1 Chain A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQI
CEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRT
YVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAI
DRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEY
LHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNN
LLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK
TMRQELDDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPN
Ligand information
>8ei1 Chain E (length=17) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DPADRWCELAAWTCDTF
Receptor-Ligand Complex Structure
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PDB8ei1 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
Resolution2.89 Å
Binding residue
(original residue number in PDB)		V488 P491 M497 R498 L501 D502 K505 K527 F530 F533 I534 R537 P538
Binding residue
(residue number reindexed from 1)		V293 P296 M302 R303 L306 D307 K310 K332 F335 F338 I339 R342 P343
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ei1, PDBe:8ei1, PDBj:8ei1
PDBsum8ei1
PubMed37914719
UniProtQ13620|CUL4B_HUMAN Cullin-4B (Gene Name=CUL4B)

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