Structure of PDB 8efk Chain A Binding Site BS01

Receptor Information
>8efk Chain A (length=598) Species: 8187 (Lates calcarifer) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFSIIDVASDRRLFNTFIKEWKTKERYSLALACEKREHDSDGLVLIGLSV
CWGARDSYYISLQQVSERLGQVRSCLSRPGGVVVTYDIIQVYKTLVLSCG
ISLAGNCEDPKVACWLLDPGSEERTLPNMVTVYCPEELPLLDGLGSAHAH
CPRVRAATKSVLVHAVMNHLTGLLEKDSMLDLFRSIEMPSQVCLALLELN
GVGFSVEECERQKHVMQAKLTALESQAYNLAGHSFSLTSIDDIAQVLFLE
LHLPFSTTKDILEKLRPLHPLPGVILEWRRITNALTKVVFPLQREKQYHP
TLAMDRIYPIAQTHTATGRVSFTEPNIQNVPKDFEICMAFSVSMRHAFVP
FSGGMILAADYSQLELRVLAHLSKDQRLLQVLNGGADVFRCIAAEWKGVD
PETVNDSLRQQAKQICYGIIYGMGAKSLGEQMGVEENDAACYIESFKARY
KGINAFLKETVKNCIKNGYVQTLMGRRRYLPGISNTNTHIKAHAERQAVN
TTVQGSAADIVKLATVNIQKRLRKTYPTAPLSHQHTLRGAFFVLQLHDEL
IYETREEDLIQVAQIVKREMESAVKLYVKLKAKVKVGPSWGNLQDLDL
Ligand information
Receptor-Ligand Complex Structure
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PDB8efk Structural basis of DNA polymerase theta mediated DNA end joining.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T2321 K2322 T2380 R2382 Q2391 N2392 P2394 K2395 R2448 G2521 Y2524 M2526 G2527 S2530 R2581 H2592 H2596 R2599 Q2600 N2603 Q2607 L2662
Binding residue
(residue number reindexed from 1)		T258 K259 T317 R319 Q328 N329 P331 K332 R345 G418 Y421 M423 G424 S427 R478 H489 H493 R496 Q497 N500 Q504 L546
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8efk, PDBe:8efk, PDBj:8efk
PDBsum8efk
PubMed36583344
UniProtA0A4W6BKE5

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