Structure of PDB 8efc Chain A Binding Site BS01

Receptor Information
>8efc Chain A (length=595) Species: 8187 (Lates calcarifer) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFSIIDVASDRRLFNTFIKEWKTKERYSLALACEKREHDSDGLVLIGLSV
CWGARDSYYISLQQVSERLGQVRSCLSRPGGVVVTYDIIQVYKTLVLSCG
ISLAGNCEDPKVACWLLDPGSEERTLPNMVTVYCPEELPLLDGLAHCPRV
RAATKSVLVHAVMNHLTGLLEKDSMLDLFRSIEMPSQVCLALLELNGVGF
SVEECERQKHVMQAKLTALESQAYNLAGHSFSLTSIDDIAQVLFLELHLP
QFSTTKDILEKLRPLHPLPGVILEWRRITNALTKVVFPLQREKQYHPTLA
MDRIYPIAQTHTATGRVSFTEPNIQNVPKDFEICMAFSVSMRHAFVPFSG
GMILAADYSQLELRVLAHLSKDQRLLQVLNGGADVFRCIAAEWKGVDPET
VNDSLRQQAKQICYGIIYGMGAKSLGEQMGVEENDAACYIESFKARYKGI
NAFLKETVKNCIKNGYVQTLMGRRRYLPGISNTNTHIKAHAERQAVNTTV
QGSAADIVKLATVNIQKRLRKTYPTAPLSHQHTLRGAFFVLQLHDELIYE
TREEDLIQVAQIVKREMESAVKLYVKLKAKVKVGPSWGNLQDLDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8efc Structural basis of DNA polymerase theta mediated DNA end joining.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T2378 A2379 T2380 S2384 T2386 G2521 Y2524 M2526 G2527 K2529 S2530 R2581 A2595 H2596 R2599 Q2600 N2603 Q2607
Binding residue
(residue number reindexed from 1)		T312 A313 T314 S318 T320 G415 Y418 M420 G421 K423 S424 R475 A489 H490 R493 Q494 N497 Q501
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8efc, PDBe:8efc, PDBj:8efc
PDBsum8efc
PubMed36583344
UniProtA0A4W6BKE5

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