Structure of PDB 8ef9 Chain A Binding Site BS01

Receptor Information
>8ef9 Chain A (length=599) Species: 8187 (Lates calcarifer) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFSIIDVASDRRLFNTFIKEWKTKERYSLALACEKREHDSDGLVLIGLSV
CWGARDSYYISLQQVSERLGQVRSCLSRPGGVVVTYDIIQVYKTLVLSCG
ISLAGNCEDPKVACWLLDPGSEERTLPNMVTVYCPEELPLLDGLGSAHAH
CPRVRAATKSVLVHAVMNHLTGLLEKDSMLDLFRSIEMPSQVCLALLELN
GVGFSVEECERQKHVMQAKLTALESQAYNLAGHSFSLTSIDDIAQVLFLE
LHLPQFSTTKDILEKLRPLHPLPGVILEWRRITNALTKVVFPLQREKQYH
PTLAMDRIYPIAQTHTATGRVSFTEPNIQNVPKDFEICMAFSVSMRHAFV
PFSGGMILAADYSQLELRVLAHLSKDQRLLQVLNGGADVFRCIAAEWKGV
DPETVNDSLRQQAKQICYGIIYGMGAKSLGEQMGVEENDAACYIESFKAR
YKGINAFLKETVKNCIKNGYVQTLMGRRRYLPGISNTNTHIKAHAERQAV
NTTVQGSAADIVKLATVNIQKRLRKTYPTAPLSHQHTLRGAFFVLQLHDE
LIYETREEDLIQVAQIVKREMESAVKLYVKLKAKVKVGPSWGNLQDLDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ef9 Structural basis of DNA polymerase theta mediated DNA end joining.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T2272 I2274 D2275 K2350 Q2375 T2378 A2379 S2384 T2386 N2389 G2521 Y2524 M2526 G2527 S2530 R2581 A2595 H2596 R2599 Q2600 N2603 Q2607
Binding residue
(residue number reindexed from 1)		T238 I240 D241 K288 Q313 T316 A317 S322 T324 N327 G419 Y422 M424 G425 S428 R479 A493 H494 R497 Q498 N501 Q505
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ef9, PDBe:8ef9, PDBj:8ef9
PDBsum8ef9
PubMed36583344
UniProtA0A4W6BKE5

[Back to BioLiP]