Structure of PDB 8ebm Chain A Binding Site BS01
Receptor Information
>8ebm Chain A (length=323) Species:
9606
(Homo sapiens) [
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ACPAERSGHVAVSDGRHMFVWGGYKSNFYLPREELWIYNMETGRWKKINT
EGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRRVLQWERID
CQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSS
HPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGR
YRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGG
FTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFG
GCANNLLVHHRAAHSNEILIFSV
Ligand information
>8ebm Chain C (length=6) Species:
9606
(Homo sapiens) [
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NNTSGS
Receptor-Ligand Complex Structure
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PDB
8ebm
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Resolution
1.58 Å
Binding residue
(original residue number in PDB)
Y50 S92 H109 K147 Y163 R189 W191 R236 R241 S269 W270 H345
Binding residue
(residue number reindexed from 1)
Y24 S59 H76 K111 Y127 R153 W155 R200 R205 S233 W234 H309
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8ebm
,
PDBe:8ebm
,
PDBj:8ebm
PDBsum
8ebm
PubMed
36805027
UniProt
Q9Y2U9
|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)
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