Structure of PDB 8e8w Chain A Binding Site BS01

Receptor Information
>8e8w Chain A (length=452) Species: 285532 (Streptomyces achromogenes subsp. streptozoticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLP
HLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRA
FYSPANRALGERIRPALERYAFGFLDDEVGTWTAQSLDAYLDSLEQSPVE
KAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVV
IDEYGGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYL
GKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIH
GRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWMD
AQPELKKLHDPVFEGLKQGKVAPVAHLVEPRGELSNTHCHDGDELCHIVS
GTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRK
CL
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain8e8w Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e8w Crystal structure of SznF from Streptomyces achromogenes var. streptozoticus NRRL 2697 mononuclear Fe(II) structure on the HDO cofactor assembly pathway
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E189 E215 H225 H311
Binding residue
(residue number reindexed from 1)		E177 E203 H212 H298
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.13.250: nitrosourea synthase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8e8w, PDBe:8e8w, PDBj:8e8w
PDBsum8e8w
PubMed
UniProtA0A411MR89|SZNF_STRC2 Nitrosourea synthase (Gene Name=sznF)

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