Structure of PDB 8e6n Chain A Binding Site BS01

Receptor Information
>8e6n Chain A (length=398) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RILPFLGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVI
QNLSANLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGA
ALAIQLLTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGV
AYLVQVVLARPDLAAVGAGFVPRLQGPGSAYLAVWIIGATVMPHVIYLHS
ALTQGRIQTDTTEEKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHG
KNVENAGDLTTAYQTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVI
MQGFMGFHIPLWLRRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFA
LVPLLLFTARRDVMGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8e6n Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8e6n High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		A53 D56 N59 M230
Binding residue
(residue number reindexed from 1)		A15 D18 N21 M192
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006828 manganese ion transport
GO:0030001 metal ion transport
GO:0034755 iron ion transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8e6n, PDBe:8e6n, PDBj:8e6n
PDBsum8e6n
PubMed37039477
UniProtQ9RTP8|MNTH_DEIRA Divalent metal cation transporter MntH (Gene Name=mntH)

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