Structure of PDB 8e6l Chain A Binding Site BS01

Receptor Information
>8e6l Chain A (length=385) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVIQNLS
ANLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAI
QLLTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGVAYLV
QVVLARPDLAAVGAGFVPRLQGPGSAYLAVGIIGATVMPHVIYLHSATTE
EKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHGKNVENAGALTTAY
QTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVIMQGFMGFHIPLWL
RRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFALVPLLLFTARRDV
MGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8e6l Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8e6l High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		D56 N59 A227 M230
Binding residue
(residue number reindexed from 1)		D14 N17 A185 M188
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006828 manganese ion transport
GO:0030001 metal ion transport
GO:0034755 iron ion transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e6l, PDBe:8e6l, PDBj:8e6l
PDBsum8e6l
PubMed37039477
UniProtQ9RTP8|MNTH_DEIRA Divalent metal cation transporter MntH (Gene Name=mntH)

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