Structure of PDB 8e6i Chain A Binding Site BS01

Receptor Information
>8e6i Chain A (length=392) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVIQNLSAN
LGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAIQL
LTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGVAYLVQV
VLARPDLAAVGAGFVPRLQGPGSAYLAVGIIGATVAPHVIYLHSALTQGR
IQTDTTEEKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHGKNVENA
GDLTTAYQTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVIMQGFMG
FHIPLWLRRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFALVPLLL
FTARRDVMGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8e6i Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8e6i High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Resolution2.52 Å
Binding residue
(original residue number in PDB)		Y54 D56 N59 A227
Binding residue
(residue number reindexed from 1)		Y10 D12 N15 A183
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006828 manganese ion transport
GO:0030001 metal ion transport
GO:0034755 iron ion transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8e6i, PDBe:8e6i, PDBj:8e6i
PDBsum8e6i
PubMed37039477
UniProtQ9RTP8|MNTH_DEIRA Divalent metal cation transporter MntH (Gene Name=mntH)

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