Structure of PDB 8e60 Chain A Binding Site BS01

Receptor Information
>8e60 Chain A (length=393) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVIQNLSA
NLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAIQ
LLTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGVAYLVQ
VVLARPDLAAVGAGFVPRLQGPGSAYLAVGIIGATVMPHVIYLHSALTQG
RIQTDTTEEKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHGKNVEN
AGDLTTAYQTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVIMQGFM
GFHIPLWLRRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFALVPLL
LFTARRDVMGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8e60 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8e60 High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Resolution2.38 Å
Binding residue
(original residue number in PDB)
A53 Y54 D56 N59 A227 M230
Binding residue
(residue number reindexed from 1)
A10 Y11 D13 N16 A184 M187
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006828 manganese ion transport
GO:0030001 metal ion transport
GO:0034755 iron ion transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8e60, PDBe:8e60, PDBj:8e60
PDBsum8e60
PubMed37039477
UniProtQ9RTP8|MNTH_DEIRA Divalent metal cation transporter MntH (Gene Name=mntH)

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