Structure of PDB 8e4x Chain A Binding Site BS01

Receptor Information
>8e4x Chain A (length=384) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKD
AKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYL
NNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILE
EPADRHPNRKARGQLRTKIESGQGTIPVRSNASIQTWDGVLQGERLLTMS
CSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRIS
NIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINAT
TGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAA
KEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSL
Ligand information
>8e4x Chain C (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcucgcgaugcgggagggcucugauagcuacg
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Receptor-Ligand Complex Structure
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PDB8e4x ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		V351 T375 K376 H394 E396 P450 C451 R455 H460 H471 R474 K475 S486 G487 Q488 C516
Binding residue
(residue number reindexed from 1)		V36 T60 K61 H79 E81 P135 C136 R140 H145 H156 R159 K160 S171 G172 Q173 C201
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8e4x, PDBe:8e4x, PDBj:8e4x
PDBsum8e4x
PubMed36243986
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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