Structure of PDB 8e2l Chain A Binding Site BS01

Receptor Information
>8e2l Chain A (length=460) Species: 8187 (Lates calcarifer) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEDEAQLIKTMFQITKVSNATLKKFGVRLFKPTKSLVFPWFAGPDSSLKG
LKLLSAQNTDTEKVTYNEATVPKISSYYNLFGLTLVGRMDSEVVLTGHEL
DTLAVSQATGLPSVALPRGVSCLPPMLLPYLEQFKRVTLWLGHDIRSWEA
SKIFSRKLGLRRCSLVRPGEDRPCPLEALARGKNLSRIIKTSIPAAHKSI
VSFKQLREDVYGELLNTEQVAGVKWTRFPELNRILKGHRKGELTVFTGPT
GSGKTTFISEVALDLCIQGVNTLWGSFQINNVRLAKIMLTQFAMQRLEEN
LEQYDFWADKFEELPLYFMTFHGQQNIKTVLDTMQHAVYLYDINHVIIDN
LQFMMGQDKYAVQDHIIGAFRKFATNTSCHVTLIIHPRKEEDDRELQTAS
IFGSAKASQEADNVLILQEKKLVTCPGRRSLQVTKNRFDGDVGIFPLDFI
KSSLTFSAPI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8e2l Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase.
Resolution3.51 Å
Binding residue
(original residue number in PDB)		R440 K441 F454 G455 S456
Binding residue
(residue number reindexed from 1)		R388 K389 F402 G403 S404
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8e2l, PDBe:8e2l, PDBj:8e2l
PDBsum8e2l
PubMed36400570
UniProtA0A4W6C5C5

[Back to BioLiP]