Structure of PDB 8e2a Chain A Binding Site BS01

Receptor Information
>8e2a Chain A (length=686) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG
VVARNRALNGDLVVVKLSAKVVYILEKKHSRAATGFLKLLRKYALFSPSD
HRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKS
LGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRR
DLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSD
LDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTP
EGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSS
EEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHI
YEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLV
EFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMA
LYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALGYR
ERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESGPLESEA
MVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEP
EDMEQEPAQQVITIFSLVEVVLQAESTALKYSAILK
Ligand information
Receptor-Ligand Complex Structure
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PDB8e2a A shape-shifting nuclease unravels structured RNA.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D383 P384 R388 D389 D391 Y435 L551 D552 Q553 E583 H610 R616 S666 Q670 M671 H688 Y696 H698 T700 R704 K779 R794
Binding residue
(residue number reindexed from 1)		D211 P212 R216 D217 D219 Y263 L379 D380 Q381 E411 H438 R444 S494 Q498 M499 H516 Y524 H526 T528 R532 K607 R622
Enzymatic activity
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006402 mRNA catabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0010587 miRNA catabolic process
GO:0019827 stem cell population maintenance
GO:0051301 cell division
GO:0051306 mitotic sister chromatid separation
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0000932 P-body
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e2a, PDBe:8e2a, PDBj:8e2a
PDBsum8e2a
PubMed36823385
UniProtQ8IYB7|DI3L2_HUMAN DIS3-like exonuclease 2 (Gene Name=DIS3L2)

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