Structure of PDB 8e24 Chain A Binding Site BS01

Receptor Information
>8e24 Chain A (length=644) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTGFPIK
GCDDTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKES
DKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLH
SIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNS
MNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIM
QAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNTSKDVLNKLK
AHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTAT
GRITFTEPNIQNVPRDFEIKMPTLADRGMPFSISMRHAFVPFPGGSILAA
DYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLR
QQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTE
TVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAAD
IVKIATVNIQKQLETFHSTFKSHGHREGMLFCPIRGGFFILQLHDELLYE
VAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e24 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		K2209 A2238 T2239 T2243 T2245 E2246 N2248 N2251 Y2387 G2388 Y2391 M2393 G2394 S2397 R2448 N2457 Y2459 A2462 H2463 R2466 Q2467 N2470 Q2474
Binding residue
(residue number reindexed from 1)		K320 A349 T350 T354 T356 E357 N359 N362 Y458 G459 Y462 M464 G465 S468 R519 N528 Y530 A533 H534 R537 Q538 N541 Q545
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e24, PDBe:8e24, PDBj:8e24
PDBsum8e24
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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