Structure of PDB 8e23 Chain A Binding Site BS01

Receptor Information
>8e23 Chain A (length=637) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTGFPIKG
CDDTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKEKE
CSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIV
TSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQ
LNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAK
LDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREQFSTSKDVLNK
LKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSH
TATGRITFTEPNIQNVPRDFEIKMFSISMRHAFVPFPGGSILAADYSQLE
LRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQI
CYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCK
RDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIAT
VNIQKQLETFHSTFKSHGHREGMCPIRGGFFILQLHDELLYEVAEEDVVQ
VAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e23 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		T2128 S2130 T2208 A2238 T2239 T2243 T2245 E2246 N2248 N2251 Q2384 G2388 Y2391 M2393 G2394 S2397 R2448 N2457 Y2459 A2462 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		T269 S271 T322 A352 T353 T357 T359 E360 N362 N365 Q449 G453 Y456 M458 G459 S462 R513 N522 Y524 A527 H528 R531 N535 Q539
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e23, PDBe:8e23, PDBj:8e23
PDBsum8e23
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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