Structure of PDB 8e0e Chain A Binding Site BS01

Receptor Information
>8e0e Chain A (length=322) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDV
PVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMR
LQHEQRAKKRMPHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFL
KHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEI
ERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLI
KSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYL
EAYWKATHPPSSNLPNPLLSRT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8e0e Chain A Residue 511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8e0e Selective posttranslational inhibition of Ca V beta 1 -associated voltage-dependent calcium channels with a functionalized nanobody.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		G82 A84
Binding residue
(residue number reindexed from 1)		G54 A56
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e0e, PDBe:8e0e, PDBj:8e0e
PDBsum8e0e
PubMed36494348
UniProtA0A8I6AEJ4

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