Structure of PDB 8dwk Chain A Binding Site BS01

Receptor Information
>8dwk Chain A (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
Ligand information
>8dwk Chain C (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SLTIKKKVEWTSDTVDNEHMGRRSSKCC
Receptor-Ligand Complex Structure
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PDB8dwk Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E54 L55 E56 N86 E116 N117 F119 D208 N219 D220 R221 D242 V250 E252 D253 Y255 E256 F257 A259 K260 R261 C273 F276 E287 L289 M290 C291 S292 F293
Binding residue
(residue number reindexed from 1)		E49 L50 E51 N81 E111 N112 F114 D203 N214 D215 R216 D237 V245 E247 D248 Y250 E251 F252 A254 K255 R256 C268 F271 E282 L284 M285 C286 S287 F288
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8dwk, PDBe:8dwk, PDBj:8dwk
PDBsum8dwk
PubMed37002212
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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