Structure of PDB 8dwd Chain A Binding Site BS01
Receptor Information
>8dwd Chain A (length=344) Species:
1422
(Geobacillus stearothermophilus) [
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PAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSSVMLQQTRVETVIPYF
EQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGG
KVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVT
DDIAKPSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLC
PVQAYCQAFAEGVAEELPVKMKKTAVKQVPLAVAVLADDEGRVLIRKRDS
TGLLANLWEFPSCETDDGKEKLEQMVGEELTEPIVSFEHAFSHLVWQLTV
FPGRLVHGGPVEEPYRLAPEDELKAYAFPVSHQRVWREYKEWAS
Ligand information
>8dwd Chain B (length=11) [
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aagacgtggac
Receptor-Ligand Complex Structure
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PDB
8dwd
Structural Basis for Base Engagement and Stereochemistry Revealed by Alteration of Catalytic Residue Glu43 in DNA Repair Glycosylase MutY
Resolution
1.68 Å
Binding residue
(original residue number in PDB)
Q48 R50 G85 G87 Y88 Y89 G260 L261 L262 H305 F307 S308 H309 V346
Binding residue
(residue number reindexed from 1)
Q40 R42 G77 G79 Y80 Y81 G252 L253 L254 H289 F291 S292 H293 V330
Enzymatic activity
Enzyme Commision number
3.2.2.31
: adenine glycosylase.
Gene Ontology
Molecular Function
GO:0000701
purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677
DNA binding
GO:0003824
catalytic activity
GO:0016798
hydrolase activity, acting on glycosyl bonds
GO:0019104
DNA N-glycosylase activity
GO:0032357
oxidized purine DNA binding
GO:0034039
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0035485
adenine/guanine mispair binding
GO:0046872
metal ion binding
GO:0051539
4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281
DNA repair
GO:0006284
base-excision repair
GO:0006298
mismatch repair
GO:0006950
response to stress
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:8dwd
,
PDBe:8dwd
,
PDBj:8dwd
PDBsum
8dwd
PubMed
UniProt
P83847
|MUTY_GEOSE Adenine DNA glycosylase (Gene Name=mutY)
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