Structure of PDB 8dwd Chain A Binding Site BS01

Receptor Information
>8dwd Chain A (length=344) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSSVMLQQTRVETVIPYF
EQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGG
KVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVT
DDIAKPSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLC
PVQAYCQAFAEGVAEELPVKMKKTAVKQVPLAVAVLADDEGRVLIRKRDS
TGLLANLWEFPSCETDDGKEKLEQMVGEELTEPIVSFEHAFSHLVWQLTV
FPGRLVHGGPVEEPYRLAPEDELKAYAFPVSHQRVWREYKEWAS
Ligand information
Receptor-Ligand Complex Structure
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PDB8dwd Structural Basis for Base Engagement and Stereochemistry Revealed by Alteration of Catalytic Residue Glu43 in DNA Repair Glycosylase MutY
Resolution1.68 Å
Binding residue
(original residue number in PDB)
Q48 R50 G85 G87 Y88 Y89 G260 L261 L262 H305 F307 S308 H309 V346
Binding residue
(residue number reindexed from 1)
Q40 R42 G77 G79 Y80 Y81 G252 L253 L254 H289 F291 S292 H293 V330
Enzymatic activity
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Gene Ontology
Molecular Function
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0032357 oxidized purine DNA binding
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0035485 adenine/guanine mispair binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006298 mismatch repair
GO:0006950 response to stress

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Molecular Function

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Biological Process
External links
PDB RCSB:8dwd, PDBe:8dwd, PDBj:8dwd
PDBsum8dwd
PubMed
UniProtP83847|MUTY_GEOSE Adenine DNA glycosylase (Gene Name=mutY)

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