Structure of PDB 8dvm Chain A Binding Site BS01

Receptor Information
>8dvm Chain A (length=612) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWT
DISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRI
EVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD
GSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI
LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC
SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQL
YWIDSRQNMIRKAQEDGSQGFTVVVSLEIQPYDLSIDIYSRYIYWTCEAT
NVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIER
AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN
RIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARI
AQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLV
LLQDELSCGEPP
Ligand information
>8dvm Chain B (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GCRWFMKWFPPHWCG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8dvm Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R639 E663 I681 S682 D705 Y706 E708 T724 W767 R792 W850 Y875
Binding residue
(residue number reindexed from 1)		R10 E34 I52 S53 D76 Y77 E79 T95 W138 R163 W221 Y246
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8dvm, PDBe:8dvm, PDBj:8dvm
PDBsum8dvm
PubMed36893429
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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