Structure of PDB 8dvl Chain A Binding Site BS01

Receptor Information
>8dvl Chain A (length=610) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWT
DISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRI
EVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD
GSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI
LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC
SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQL
YWIDSRQNMIRKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEATN
VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERA
ALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR
IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIA
QLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL
LQDELSCGEP
Ligand information
>8dvl Chain B (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GCIPVITTRGVRCK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8dvl Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y706 E708 T724 S749 W767 G768 R792 Y875
Binding residue
(residue number reindexed from 1)		Y77 E79 T95 S120 W138 G139 R163 Y246
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8dvl, PDBe:8dvl, PDBj:8dvl
PDBsum8dvl
PubMed36893429
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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