Structure of PDB 8dny Chain A Binding Site BS01

Receptor Information
>8dny Chain A (length=456) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIM
SSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD
TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQ
LFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTG
RGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAV
VIYFQGFRYELPIRSTKVRGQIGIYPIKLFYTSNIPIILQSALVSNLYVI
SQMLSARFSGNLLVSLLGTWSRAYPVGGLCYYLSPPESFGSVLEDPVHAV
VYIVFMLGSCAFFSKTWIEVSGSSPRDIAKQFKDQGMVINGKRETSIYRE
LKKIIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFV
KEQSEV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8dny A common mechanism of Sec61 translocon inhibition by small molecules.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		F62 M65 I68 L69 S82 V85 T86 Q127 Y131 I292 A296 L297 N300 V303 I304 F375
Binding residue
(residue number reindexed from 1)		F58 M61 I64 L65 S78 V81 T82 Q123 Y127 I288 A292 L293 N296 V299 I300 F363
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dny, PDBe:8dny, PDBj:8dny
PDBsum8dny
PubMed37169959
UniProtP61619|S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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