Structure of PDB 8dhl Chain A Binding Site BS01

Receptor Information
>8dhl Chain A (length=827) Species: 28112 (Tannerella forsythia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGRCQIAFNSGWLFSKNEANAVLPDRTTAGWQAVQLPHTWNDKDVGYYRG
VGWYKKRFRLVPEKGKRYFLRFEGVNQTAEVFVNGKPAGEHTGGYTAFNV
DLTPFLEASGEQYIAVKADNSHRDDVPPLSADFTFFGGIYRPVHLITTGE
QHFSMSDYGGPGIYITTPRVTPHGADVTITYHLQNCSDAPQALTLETVIR
KDVASALATKNTAVTISAFGDTVVTVTCSDVRNFDLWSPDHPAMYYVESL
LKQSGKRVDNLSQPLGFRWFRFDPEKGFFINGKNIKLMGANRHQDRIPYG
NALSNDMHRQDLSLLKEMGGNFLRNAHYPQADEVLDQADRLGFAVWEEIP
LVNEVTVGPRHTENTTVMLKEMIKQHYNHPSVVIWAYMNEIYWAHRYKPQ
EEIAGRNRATLELARRLEHIVRELDPYRYTAMAMHNDPAYEETGLGDIPM
IAGWNLYHGWYYGIYEDFGTFMDEQRRKYPKRIHLISEYGAGSDVRLYSE
KPEKFDFTVEEQTRFTRSITTQILDRPYIAGGALWNLADFSSENNKGLVT
ADRKPKDAYYLMQALLSEKPVARLGYPFRNRWVHAATSPSDTLVPVRMHA
FSNQKSVSLYVDNRLFGEAEVKDGMAEWEMKLIPGRHLLSLAPNSPDTPE
KQIDVRLIPFRPDGKLAMNVGANYAFIDTRTDLYWLPERTYEKGSWGVVG
GEPLYVGGKVGTKEDILAVDEEDPLYQTMRVNPEGFGADLPDGTYEIELL
MVDYVITYEPGQRVFGVSVNGTSILPEIDLGGSYGLNVPCRLTFRYTVTD
NAGLSIKFHPVSGEPVLSAVRIRKVEF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8dhl Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8dhl Microbial beta-glucuronidases drive human periodontal disease etiology.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		I762 V765 D769
Binding residue
(residue number reindexed from 1)		I716 V719 D723
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8dhl, PDBe:8dhl, PDBj:8dhl
PDBsum8dhl
PubMed37146137
UniProtG8UKC1

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