Structure of PDB 8d7m Chain A Binding Site BS01

Receptor Information
>8d7m Chain A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d7m PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		G18 S19 D128 K130 L152 L173 T174 G175 R178 Q214 G215 K224 Y225
Binding residue
(residue number reindexed from 1)		G17 S18 D127 K129 L151 L172 T173 G174 R177 Q213 G214 K223 Y224
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d7m, PDBe:8d7m, PDBj:8d7m
PDBsum8d7m
PubMed37207626
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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